RESUMO
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations
Assuntos
Calotropis/química , Cebolas/citologia , Cebolas/crescimento & desenvolvimento , Cebolas , Citotoxinas/efeitos adversos , Citotoxinas/farmacologia , Látex/efeitos adversos , Látex/farmacologia , Podofilotoxina/efeitos adversos , Podofilotoxina/farmacologia , Ciclofosfamida/efeitos adversos , Meristema/crescimento & desenvolvimento , Meristema/efeitos adversos , MitoseRESUMO
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations(AU)
Assuntos
Citotoxinas/efeitos adversos , Citotoxinas/farmacologia , Látex/efeitos adversos , Látex/farmacologia , Calotropis/química , Podofilotoxina/efeitos adversos , Podofilotoxina/farmacologia , Cebolas/citologia , Cebolas/efeitos dos fármacos , Cebolas/crescimento & desenvolvimento , Ciclofosfamida/efeitos adversos , Meristema/efeitos adversos , Meristema/crescimento & desenvolvimento , Mitose/efeitos dos fármacosRESUMO
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations(AU)
